Semax (25mg)

Peptide Analog Synthesis: The Case of Semaxancement

Semax peptide stands as a synthetic polypeptide analog derived from adrenocorticotropic hormone fragment 4-10 (ACTH 4-10), a natural hormone fragment originating from the anterior pituitary gland.(1) This fragment, while not mirroring the actions of ACTH itself, is theorized to exert specific effects on the brain.(2) In the intricate landscape of naturally occurring peptides governing vital regulatory systems, instability and susceptibility to enzymatic degradation in bodily fluids pose challenges. As a remedy, researchers endeavor to craft analogs of these peptides, seeking to engineer synthetics that replicate biological actions while boasting enhanced stability.

Overview

Investigations into the synthesized Semax peptide have been extensive, delving into its putative mechanism of action and scrutinizing its stability. Notably, researchers propose that Semax might exert inhibitory effects on specific enzymes responsible for the degradation of enkephalins—naturally occurring neurotransmitters deemed pivotal in regulating diverse biological functions, particularly within the brain. Beyond enkephalins, Semax could potentially inhibit other enzymes involved in peptide degradation. According to a research study,(4) Semax is implicated in inducing heightened dopamine secretion and release, potentially elevating brain-derived neurotrophic factor (BDNF) levels. Another study(5) suggests that Semax may possess the capacity to influence gene expressions that modulate the immune system, potentially enhancing the levels and mobility of immune cells. Furthermore, researchers noted Semax’s capacity to impact the encoding of chemokines and immunoglobulins, offering insights into its potential influence on vascular system functionality.

Scientific Investigations and Medical Trials

Semax Peptide and Cognitive Enhancement: Exploring Nootropic Effects

In the realm of cognitive enhancement, an initial investigation(6) centered on the ACTH hormone and its analogs, including Semax, aimed to discern their potential nootropic impact in rodents. Following the administration of the peptide, the study monitored the levels of 5-hydroxyindoleacetic acid (5-HIAA). Results indicated a 25% elevation in 5-HIAA levels after 2 hours of Semax exposure, progressively reaching a peak increase of 180% within 4 hours. Researchers observed that when Semax was administered 20 minutes prior to D-amphetamine, it led to a further elevation of 5-HIAA compared to Semax alone. These findings offer insights into the potential cognitive-enhancing effects of Semax Peptide, shedding light on its nootropic properties in experimental settings.

Semax Peptide and Early-Life Anxiety: Exploring Neonatal Effects

Exploring the influence on early-life anxiety, a study focused on neonatal rats exposed to a selective serotonin reuptake inhibitor (SSRI) and subsequent Semax administration. The SSRI-exposed rats displayed anxiety-like behavior initially, marked by impaired responses to stress and stimuli. However, when Semax was introduced, these behaviors were altered, showcasing improved learning abilities and reduced anxiety. Researchers proposed that Semax may have restored normal monoamine levels in the rat’s brain, countering the SSRI-induced decrease. This suggests Semax Peptide’s potential in mitigating anxiety-related behaviors during early development.

Semax Peptide and Cardiac Protection: Examining Vascular Impact

A study(8) delved into the potential of Semax to safeguard the rat heart from vascular damage following myocardial infarction (MI). Rats undergoing MI were surgically treated, with some receiving Semax for the subsequent 6 days. On the 28th day post-MI, researchers observed that rats without Semax developed cardiac hypertrophy coupled with reduced arterial blood pressure. In contrast, Semax-administered rats displayed indications suggestive of the prevention of diastolic pressure growth in the left ventricle, alongside apparent left ventricle remodeling. These findings highlight the potential of Semax Peptide in conferring protective effects on the vascular system, particularly in the context of myocardial infarction.

Semax Peptide and Early-Life Stress: Evaluating Effects on Adolescents

A study(9) focused on adolescent rats subjected to maternal separation for approximately 5 hours daily from postnatal days 1 to 14, followed by Semax administration from days 15 to 28. Results after 28 days indicated that during periods of maternal deprivation without Semax, the rats exhibited heightened anxiety and increased physical and emotional reactivity. However, in the presence of Semax, researchers noted a restoration of reactions and anxiety levels in the rats to those resembling control conditions. This suggests that Semax Peptide may play a role in mitigating the adverse effects of early-life stress during crucial developmental stages.

Semax Peptide in Ischemic Stroke: Exploring Neuroprotective Effects

A clinical trial(10) involving 100 test subjects with ischemic stroke investigated the impact of Semax. Among them, 30 subjects received Semax, while the remainder constituted the control group. The study revealed that in the presence of Semax, there was observable enhancement in the restoration rate of impaired neurological functions. The assessment of all outcomes was conducted using EEG mapping, providing insights into the potential neuroprotective effects of Semax Peptide in the context of ischemic stroke.

Semax Peptide and Cognitive Enhancement: Investigating Nootropic Effects

In a limited clinical trial(11), male test subjects were administered Semax under high-stress conditions, and their brain activity was closely observed. Following the study, approximately 24 hours later, researchers noted that compared to their normal, pre-trial baseline, the subjects displayed heightened memory and attention levels. These findings suggest the potential nootropic properties of Semax Peptide in enhancing cognitive functions, particularly under stress-induced conditions.
Semax Peptide is exclusively intended for utilization in research and laboratory settings. Prior to placing an order, kindly review and comply with our stipulated Usage Guidelines and Terms and Conditions.